Multicenter Observational Study on Infant Botulism in Pediatric Intensive Care
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Abstract
Introduction. Infant botulism presents with potentially severe flaccid paralysis. Argentina has an incidence of 2.41 cases/100,000 live births.
Objective. To describe the clinical characteristics of patients with Infant botulism hospitalized in Pediatric Intensive Care Units.
Material and Methods. Retrospective, observational, multicentric study conducted between 01-01-2013 and 31/12/2019.
Results. A total of sixty patients were included, all diagnosed with the mouse bioassay. Conventional mechanical ventilation was administered to 80%, Non-Invasive Ventilation to 27%; 30% received antitoxin. The median Intensive Care stay was 25 days (IRD: +-18.5) and median conventional mechanical ventilation was 27 days (IRD +-14.5). Delay in diagnostic confirmation: median 16 days (IQR 13-18.5).
Conclusions. Infant botulism presented prolonged periods of hospitalization and mechanical ventilation; only 30% of patients received antitoxin. The diagnostic confirmation delay time exceeded the recommended antitoxin administration window.
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