Sidney Ringer (1835-1910): ciencia y serendipia en el Londres victoriano.
Barra lateral del artículo
Publicado:
jun 22, 2021
Palabras clave:
Calcio, ringer, serendipia, historia de la medicina
Contenido principal del artículo
Resumen
El trascendental rol del calcio en la función miocárdica fue reconocido hace ciento cuarenta años por el médico y fisiólogo británico Sidney Ringer (1835-1910), el cual es recordado por la mayoría de los miembros del equipo de salud por ser quien dio origen a la solución epónima, cuyo descubrimiento presentó características muy singulares. No obstante, hay otros aspectos menos patentes de su vida laboral como también sobre su biografía, dignos de considerar.
El Dr. Ringer vivió en el Londres victoriano, una época de importantes cambios, destacando como un pionero de la farmacología. El rol de la serendipia en su investigación científica le permitió aprovechar al máximo la oportunidad que se le había brindado y a su vez nos posibilitó conocer sus notables rasgos de minuciosidad, persistencia y perspicacia.
Este artículo revisa brevemente la carrera de Ringer y explora el contexto intelectual y científico en el que sus importantes contribuciones fueron efectuadas.
Detalles del artículo
Cómo citar
1.
Arriagada D. Sidney Ringer (1835-1910): ciencia y serendipia en el Londres victoriano. Rev Arg de Ter Int. [Internet]. 22 de junio de 2021 [citado 21 de diciembre de 2024];38. Disponible en: https://revista.sati.org.ar/index.php/MI/article/view/777
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Bibliografía
1. Semler MW, Self WH, Wanderer JP, Ehrenfeld JM, Wang L, Byrne DW, et al. Balanced Crystalloids versus Saline in Critically Ill Adults. N Engl J Med. 2018; 378(9):829-39.
2. Emrath ET, Fortenberry JD, Travers C, McCracken CE, Hebbar KB. Resuscitation With Balanced Fluids Is Associated With Improved Survival in Pediatric Severe Sepsis. Crit Care Med. 2017;45(7):1177-83.
3. Krajewski ML, Raghunathan K, Paluszkiewicz SM, Schermer CR, Shaw AD. Meta-analysis of high- versus low-chloride content in perioperative and critical care fluid resuscitation. Br J Surg. 2015;102(1):24-36.
4. Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatr Crit Care Med. 2020;21(2):e52-e106.
5. Obituary. Sydney Ringer, MD. Br Med J. 1910;2:1384.
6. Miller DA. Solution for the heart: The life of Sydney Ringer. London, London Physiological Society, 2007
7. Sydney Ringer (1835-1910). Clinician and pharmacologist. JAMA. 1968 ;206(11):2515-6
8. Ringer S. A further contribution regarding the influence of the different constituents of the blood on the contraction of the heart. J Physiol 1883 ;4 :29-42.
9. Zimmer HG. Sydney Ringer, serendipity, and hard work. Clin Cardiol. 2005;28(1):55-6.
10. Ringer S. Concerning the influence exerted by each of the constituents of the blood in the contraction of the ventricle. Journal of Physiol (London) 1880/82; 3:389-93.
11. Dale H. Accident and opportunism in medical research. Br Med J 1948; 11:451-5.
12. Miller DJ. Sydney Ringer; physiological saline, calcium and the contraction of the heart. J Physiol. 2004;555(Pt 3):585-7.
13. Ringer S. Regarding the Action of Hydrate of Soda, Hydrate of Ammonia, and Hydrate of Potash on the Ventricle of the Frog's Heart. J Physiol. 1882; 3(3-4):195-202.6
14. Hartmann AF, Senn MJ. Studies in the metabolism of sodium r-lactate. III. Response of human subjects with liver damage, disturbed water and mineral balance, and renal insufficiency to the intravenous injection of sodium r-lactate. J Clin Invest 1932;11(2):345-55.
15. The Physiological Society Magazine. Traces of the past. Sydney Ringer. En https://static.physoc.org/app/uploads/2019/03/22195007/29-a.pdf. Accedido el día 21 de febrero 2021.
16. Ringer S. On the connection between the heat of the body and the excreted amounts of urea, chloride of sodium, and urinary water during a fit of ague. Med Chir Soc Trans 1859; 42: 361.
17. Fye WB. Sydney Ringer, calcium, and cardiac function. Circulation. 1984;69(4):849-53.
18. Ringer S, Murrell W. On the effects of sulphate of atropia the on of frogs. J Physiol nervous system Anat 1877; 11: 321.
19. Ringer S, Murrell W. Concerning the action of chloride of potassium on the nervous system of frogs. J Anat Physiol 1878;12: 54.
20. Ringer S, Buxton DW. Concerning the Action of small quantities of Calcium, Sodium, and Potassium Salts upon the Vitality and Function of Contractile Tissue and the Cuticular Cells of Fishes. Journal of Physiology (London).1885;6:154-61.
21. Ringer S. Concerning the Influence of Saline Media on Fish, etc. J Physiol. 1884;5(2):98-115.
22. Chapman R.A. (1988) The Effect of Lime and Potash on the Frog Heart: An Imaginative Reconstruction of a Paper Presented by Sydney Ringer to the Physiological Society on 9th December 1882. In: Morad M., Nayler W.G., Kazda S., Schramm M. (eds) The Calcium Channel: Structure, Function and Implications. Bayer AG Centenary Symposium. Springer, Berlin, Heidelberg.
23. Chapman R.A. (1988) The Effect of Lime and Potash on the Frog Heart: An Imaginative Reconstruction of a Paper Presented by Sydney Ringer to the Physiological Society on 9th December 1882. In: Morad M., Nayler W.G., Kazda S., Schramm M. (eds) The Calcium Channel: Structure, Function and Implications. Bayer AG Centenary Symposium. Springer, Berlin, Heidelberg.
24. Lee JA. Sydney Ringer (1834-1910) and Alexis Hartmann (1898-1964). Anaesthesia 1981;36:1115-21
25. Biswas S, McNerney P. (2016). Sydney Ringer: The pipe water of New River Water Company and the discovery of the elixir of life.
1. Semler MW, Self WH, Wanderer JP, Ehrenfeld JM, Wang L, Byrne DW, et al. Balanced Crystalloids versus Saline in Critically Ill Adults. N Engl J Med. 2018; 378(9):829-39.
2. Emrath ET, Fortenberry JD, Travers C, McCracken CE, Hebbar KB. Resuscitation With Balanced Fluids Is Associated With Improved Survival in Pediatric Severe Sepsis. Crit Care Med. 2017;45(7):1177-83.
3. Krajewski ML, Raghunathan K, Paluszkiewicz SM, Schermer CR, Shaw AD. Meta-analysis of high- versus low-chloride content in perioperative and critical care fluid resuscitation. Br J Surg. 2015;102(1):24-36.
4. Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatr Crit Care Med. 2020;21(2):e52-e106.
5. Obituary. Sydney Ringer, MD. Br Med J. 1910;2:1384.
6. Miller DA. Solution for the heart: The life of Sydney Ringer. London, London Physiological Society, 2007
7. Sydney Ringer (1835-1910). Clinician and pharmacologist. JAMA. 1968 ;206(11):2515-6
8. Ringer S. A further contribution regarding the influence of the different constituents of the blood on the contraction of the heart. J Physiol 1883 ;4 :29-42.
9. Zimmer HG. Sydney Ringer, serendipity, and hard work. Clin Cardiol. 2005;28(1):55-6.
10. Ringer S. Concerning the influence exerted by each of the constituents of the blood in the contraction of the ventricle. Journal of Physiol (London) 1880/82; 3:389-93.
11. Dale H. Accident and opportunism in medical research. Br Med J 1948; 11:451-5.
12. Miller DJ. Sydney Ringer; physiological saline, calcium and the contraction of the heart. J Physiol. 2004;555(Pt 3):585-7.
13. Ringer S. Regarding the Action of Hydrate of Soda, Hydrate of Ammonia, and Hydrate of Potash on the Ventricle of the Frog's Heart. J Physiol. 1882; 3(3-4):195-202.6
14. Hartmann AF, Senn MJ. Studies in the metabolism of sodium r-lactate. III. Response of human subjects with liver damage, disturbed water and mineral balance, and renal insufficiency to the intravenous injection of sodium r-lactate. J Clin Invest 1932;11(2):345-55.
15. The Physiological Society Magazine. Traces of the past. Sydney Ringer. En https://static.physoc.org/app/uploads/2019/03/22195007/29-a.pdf. Accedido el día 21 de febrero 2021.
16. Ringer S. On the connection between the heat of the body and the excreted amounts of urea, chloride of sodium, and urinary water during a fit of ague. Med Chir Soc Trans 1859; 42: 361.
17. Fye WB. Sydney Ringer, calcium, and cardiac function. Circulation. 1984;69(4):849-53.
18. Ringer S, Murrell W. On the effects of sulphate of atropia the on of frogs. J Physiol nervous system Anat 1877; 11: 321.
19. Ringer S, Murrell W. Concerning the action of chloride of potassium on the nervous system of frogs. J Anat Physiol 1878;12: 54.
20. Ringer S, Buxton DW. Concerning the Action of small quantities of Calcium, Sodium, and Potassium Salts upon the Vitality and Function of Contractile Tissue and the Cuticular Cells of Fishes. Journal of Physiology (London).1885;6:154-61.
21. Ringer S. Concerning the Influence of Saline Media on Fish, etc. J Physiol. 1884;5(2):98-115.
22. Chapman R.A. (1988) The Effect of Lime and Potash on the Frog Heart: An Imaginative Reconstruction of a Paper Presented by Sydney Ringer to the Physiological Society on 9th December 1882. In: Morad M., Nayler W.G., Kazda S., Schramm M. (eds) The Calcium Channel: Structure, Function and Implications. Bayer AG Centenary Symposium. Springer, Berlin, Heidelberg.
23. Chapman R.A. (1988) The Effect of Lime and Potash on the Frog Heart: An Imaginative Reconstruction of a Paper Presented by Sydney Ringer to the Physiological Society on 9th December 1882. In: Morad M., Nayler W.G., Kazda S., Schramm M. (eds) The Calcium Channel: Structure, Function and Implications. Bayer AG Centenary Symposium. Springer, Berlin, Heidelberg.
24. Lee JA. Sydney Ringer (1834-1910) and Alexis Hartmann (1898-1964). Anaesthesia 1981;36:1115-21
25. Biswas S, McNerney P. (2016). Sydney Ringer: The pipe water of New River Water Company and the discovery of the elixir of life.