Medidas de resucitación precoz durante la pandemia de gripe a (H1N1). Se beneficiaron los pacientes?
PDF

Archivos suplementarios

Medidas de resucitación precoz durante la pandemia de gripe a (H1N1). Se beneficiaron los pacientes?
Medidas de resucitación precoz durante la pandemia de gripe a (H1N1). Se beneficiaron los pacientes?

Palabras clave

Pandemia gripe A H1N1
Sepsis
resucitacion inicial en sepsis

Cómo citar

1.
DUARTE DA. Medidas de resucitación precoz durante la pandemia de gripe a (H1N1). Se beneficiaron los pacientes?. Rev Arg de Ter Int. [Internet]. 17 de noviembre de 2011 [citado 24 de abril de 2024];28(4). Disponible en: https://revista.sati.org.ar/index.php/MI/article/view/282

Resumen

Objetivo: Evaluar el impacto en la utilización de un protocolo de medidas de detección y resucitación precoz durante la pandemia H1 N1 sobre el ingreso de pacientes al Servicio de Terapia Intensiva (STI). Diseño: Estudio observacional y retrospectivo de pacientes críticos. Ámbito: Un STI médico-quirúrgica. Pacientes: Adultos ingresados al STI desde el Servicio de Urgencia (SU) entre el 28 de abril 2009 al 04 de setiembre 2009. Variables de interés principal: Sexo, edad, comorbilidades, APACHE II, SOFA score de ingreso al STI (Sepsis- related Organ Failure Assesment), sintomatología clínica, imágenes radiográficas, necesidad de asistencia respiratoria mecánica (NARM), Ac. Láctico (mg/dl) (AL),Creatinfososquinasa (CPK) (U/l), lacticodeshidrogenas (LDH) (U/l), leucocitosis, Saturación de O2 al ingreso al STI ( Sat.O2), PaO2/FiO2 ingreso STI, presión al final de la espiración(PEEP), días de ARM (DARM),tratamiento con oseltamivir (dosis/ tiempo),Aislamiento Bacteriológico (AB) y Virológico (AV) en secreción bronquial, tratamiento con corticoides, estadía en TI (ET), y Mortalidad (M).Resultados: Se incluyeron 13 pacientes ingresados al STI en el periodo estudiado, donde la edad media fue: 45 +/- 3, sexo femenino n=8  61.5%, comorbilidades n= 7  53.8%,  (EPOC n=3, DBT n= 2, Insuficiencia Cardiaca n=1, Cirrosis n= 1), APACHE II: 18, SOFA de Ingreso 9+/-2, la sintomatología clínica predominante fue la: Fiebre n= 13  100%, tos n=11 84.6%, disnea n= 9  69.2%, infiltrados interticiales 5/13  38.4 %, opacidades alveolares 6/13  46.1%, opacidades mixtas 2/13  15.3%, 4 cuadrantes 9/13   69.2% y 2 cuadrantes 4/13  30.7%, la media de: AL 25 mg/dl, CPK 480(U/l) (p< 0.05), LDH 2100 (U/l) (p< 0.001), leucocitosis 12.500 mm3,PEEP 18 cmH2O, Sat. O2 < 91 % n=11   84.6%, PaO2/FiO2 < 150 n=11  84.6%, NARM n=11  84.6%, DARM 9.5 +/- 3 días, Oseltamivir: dosis150 mg/12 hs.; AB (Neumococo: n= 7  53.8%); AV (H1 N1: n= 5  38.4%) duración: 9.5+/- 3 días, Corticoides n=8  61.5%.  ET 11+/-4, no se registro fallecidos. Conclusión: En el grupo estudiado la aplicación de un protocolo que evalúo la gravedad beneficio en la correcta evaluación y resucitación inicial. Los valores de CPK, LDH se acompaño de mayor gravedad gasométrica y compromiso radiológico en la radiología de tórax.


PDF

Citas

<p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><strong><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US"><span style="font-size: small;">Referencias</span></span></strong></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: FR; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="FR">1.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: FR;" lang="FR"> </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: FR; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="FR">Hughes JM, La Montagne JR. </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-US">Emerging infectious diseases. J Infect Dis 1994; 170:265-71.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-US">2.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US;" lang="EN-US"> </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-US">Heymann DL, Rodier GR. Hot spots in a wired world: who surveillance emerging and reemerging infectious diseases. </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: FR; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="FR">Lancet Infect Dis 2001;1:345-53.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-US">3.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US;" lang="EN-US"> </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-US">McDade JE, Hughes JM. New and emerging infectious diseases. En: Man-dell GL, Bennett JE,Dolin R, editores. Principles and practice of infectious diseases. 5th ed. Philadelphia: Churchill Livingstone, 2000; p. 118-83.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-US">4.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US;" lang="EN-US"> </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-US">Heymann DL, Rodier GR. Hot spots in a wired world: who surveillance emerging and reemerging infectious diseases. </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: FR; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="FR">Lancet Infect Dis 2001;1:345-53.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="ES">5<strong>.</strong></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: #0a0905;" lang="ES"> </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="ES">Dawood FS, S Jain, Finelli L, et al: Aparici&oacute;n de una nueva influenza porcina de origen el virus A (H1N1) en seres humanos. N Engl J Med 2009; 360:2605-2615.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="ES">6.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: #0a0905;" lang="ES"> </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="ES">Human infecci&oacute;n por nuevo virus de influenza A (H1N1): M&eacute;xico, actualizar, marzo-mayo de 2009. Wkly Epidemiol Rec 2009; 84:213-219<span style="mso-spacerun: yes;">&nbsp; </span></span></span></p><p class="MsoNormal" style="line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="ES">7. </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-font-kerning: 18.0pt;" lang="ES">Chan M Centro de Prensa.OMS.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="ES">El nivel de alerta de pandemia de gripe se eleva de la fase 5 a la fase 6.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-bidi-font-weight: bold;" lang="ES">http://www.who.int/mediacentre/news/statements/2009/h1n1_pandemic_phase6_20090611</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="ES"><span style="font-size: small;">&nbsp;</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: ES-AR; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;">8. Ministerio de Salud de Argentina, Presidencia de la Naci&oacute;n Argentina Campa&ntilde;a Nacional de Vacunaci&oacute;n para el Nuevo Virus de Influenza A H1N1 en Argentina, 2010. </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-US">1- 26.<strong></strong></span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-US">9. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: FR; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="FR">N Engl J Med 2003; 348:138-50.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: FR; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="FR">10. Annane D, Bellissant E, Cavaillon JM. </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-US">Septic shock. Lancet 2005;365:63-78. 3. Russell JA. Management of sepsis. N Engl J Med 2006; 355:1699-713.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: ES-AR; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;"><span style="font-size: small;">11. Dougnac A, Mercado M, Cornejo R, Cariaga M, Hern&aacute;ndez G, Andresen M et al. Prevalencia de sepsis grave en las Unidades de Cuidado Intensivo. Primer estudio nacional multic&eacute;ntrico. Rev M&eacute;d Chil 2007; 135:620-30.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-US"><span style="font-size: small;">12. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R et al. Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36:296-327.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-US"><span style="font-size: small;">13. Holcomb BW, Wheeler AP, Ely EW. New ways to reduce unnecessary variation and improve outcomes in the intensive care unit. Curr Opin Crit Care 2001; 7:304-11.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-US"><span style="font-size: small;">14. Morris AH. Treatment algorithms and protocolized care. Curr Opin Crit Care 2003; 9:236-40.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-bottom-alt: auto;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-US"><span style="font-size: small;">15. Hollenberg SM, Ahrens TS, Annane D, Astiz ME, Chalfin DB, Dasta JF et al. Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update. Crit Care Med 2004; 32:1928-48.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US">16.</span><strong><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-GB; mso-fareast-language: ES-AR;" lang="EN-US"> </span></strong><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-GB; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-GB">Funk D,Sebat F, Kumar A,</span><em><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-GB; mso-fareast-language: ES-AR;" lang="EN-GB"> </span></em><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-GB; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-GB">A systems approach to the early recognition and rapid administration of best practice therapy in sepsis and septic shock. </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-GB; mso-fareast-language: ES-AR;" lang="EN-GB">Current Opinion in Critical Care 2009;15: 301- </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: DE; mso-fareast-language: ES-AR;" lang="DE">307.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: DE; mso-fareast-language: ES-AR;" lang="DE">17. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-GB; mso-fareast-language: ES-AR;" lang="EN-GB">APACHE II: a severity of disease classification system. </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US">Crit Care Med 1985; 13:818-29.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-GB; mso-fareast-language: ES-AR; mso-bidi-font-weight: bold;" lang="EN-GB">18.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-GB; mso-fareast-language: ES-AR;" lang="EN-GB">Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction failure. Intensive Care Med 1996; 22: 707-10.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; tab-stops: list 72.0pt;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: ES-AR; mso-fareast-language: ES-AR;"><span style="font-size: small;">19.<span style="color: #222222;"> </span>Rello J, Rodr&iacute;guez A, Ib&aacute;&ntilde;ez P, et al., el H1N1 SEMICYUC grupo de trabajo <em>( 2009 ) </em><span style="mso-bidi-font-style: italic;">de cuidado intensivo de pacientes adultos con insuficiencia respiratoria severa causada por la gripe A (H1N1) en Espa&ntilde;a . Cuidado de Crit 13 (5): R148</span></span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; tab-stops: list 72.0pt;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: ES-AR; mso-fareast-language: ES-AR;"><span style="font-size: small;">20.<span style="color: #222222;"> </span>Dom&iacute;nguez Cherit G, Lapinsky SE, Mac&iacute;as AE, et al. <span style="mso-bidi-font-style: italic;">(2009)<span style="mso-spacerun: yes;">&nbsp; </span>los pacientes cr&iacute;ticamente enfermos con 2009 la gripe A (H1N1) en M&eacute;xico. JAMA 302 (17): 1880 - 1887</span></span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-GB; mso-fareast-language: ES-AR;" lang="EN-GB">21.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US">Perez-Padilla R, Zamboni DR, et al., for the INER Working Group on Influenza*.Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: OTNEJMScalaSansLF; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US"> </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: OTNEJMScalaSansLF; mso-ansi-language: EN-GB; mso-fareast-language: ES-AR;" lang="EN-GB">N Engl J Med 2009; 361.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: OTNEJMScalaSansLF; mso-ansi-language: EN-GB; mso-fareast-language: ES-AR;" lang="EN-GB">22.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US"> Napolitano LM, Park PK, Sihler KC, Papadimos MD, Chenoweth C, Cinti S. Intensive-care patients with severe novel influenza A(H1N1) virus infection &ndash; Michigan, June 2009. MMWR. 2009; 58(27):749&ndash;52</span><span class="texto2"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US;" lang="EN-US">.</span></span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: OTNEJMScalaSansLF; mso-ansi-language: EN-GB; mso-fareast-language: ES-AR;" lang="EN-GB">23.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US;" lang="EN-US"> The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000;342:1301-1308.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: OTNEJMScalaSansLF; mso-ansi-language: EN-GB; mso-fareast-language: ES-AR;" lang="EN-GB">24.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-GB; mso-fareast-language: ES-AR;" lang="EN-GB"> </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: OTNEJMScalaSansLF; mso-ansi-language: EN-GB; mso-fareast-language: ES-AR;" lang="EN-GB">Rodr&iacute;guez A, D&iacute;az E, Mart&iacute;n-Loeches I, Sandiumenge A, Canadell L, D&iacute;az JJ, Figueira JC, Marqu&eacute;s A, &Aacute;lvarez-Lerma F, Vall&eacute;s J, Balad&iacute;n B, Garc&iacute;a-L&oacute;pez F, Suberviola B, Zaragoza R, Trefler S, Bonastre J, Blanquer J, Rello J, on behalf of the H1N1 SEMICYUC Working Group.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-GB; mso-fareast-language: ES-AR;" lang="EN-GB"> </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: OTNEJMScalaSansLF; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US">Impact of early oseltamivir treatment on outcome in critically ill patients with 2009 pandemic influenza A.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US"> . J Antimicrob Chemother,</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN; mso-fareast-language: ES-AR;" lang="EN"> January 7, 2011</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US"><span style="font-size: small;">25. Factors associated with early hospital discharge of adult influenza patients. Lee N, Chan PK, Choi KW, Lui G, Wong B, Cockram CS, Hui DS, Lai R, Tang JW, Sung JJ.Antivir Ther 2007; 12(4): 501-508.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US">26.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: Calibri; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US"> </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US">Martin-Loeches I, Lisboa T, Rhodes A, Moreno RP, Silva E, Sprung C, Chiche JD, Barahona D, Villabon M, Balasini C, Pearse RM, Matos R, Rello J. Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection. Intensive Care Med 2010.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span class="texto2"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US;" lang="EN-US">27.</span></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US"> Vincent JL, Abraham E. The last 100 years of sepsis. Am J Respir<span style="mso-spacerun: yes;">&nbsp; </span>Crit Care Med 2006; 173: 256-63.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US"><span style="font-size: small;">28. Otero RM, Nguyen HB, Huang DT, Gaieski DF, Goyal M, Gunnerson KJ et al. Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings. Chest 2006; 130:1579-95.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US">29. Nguyen HB, Rivers EP, Knoblich BP,Jacobsen G, Muzzin A, Ressler JA et al. Early.</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: Calibri; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US"> </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US">lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 2004; 32:1637-42.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US"><span style="font-size: small;">30. Rivers EP, Nguyen HB, Havstad S, Ressler J, Muzzin A, Knoblich B et al. Early Goal- Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345:1368-77.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-size: small;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: NL; mso-fareast-language: ES-AR;" lang="NL">31. Trzeciak S, Dellinge RP, Parrillo JE, Guglielmi M, Bajaj J, Abate NL et al. </span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US">Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med 2007;49:88-98.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US"><span style="font-size: small;">32. Gao F, Melody T, Daniels DF, Giles S, Fox S. The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study. Crit Care 2005; 9:764-70.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US"><span style="font-size: small;">33. Nguyen HB, Corbett SW, Steele R, Banta J, Clark RT, Hayes SR et al. Implementation of a bundle of quality indicators for the earlymanagement of severe sepsis and septic shock is associated with decreased mortality. Crit Care Med 2007; 35:1105-12.</span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: EN-US; mso-fareast-language: ES-AR;" lang="EN-US"><span style="font-size: small;">34. Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S et al. Duration hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34:1589-96.</span></span></p>

La revista no retiene los derechos de reproducción (copyright) por lo que los autores pueden volver a publicar sus trabajos con la sola mención a la fuente original de publicación.