Desempeño de los puntajes APACHE II y SAPS II para calcular la razón de mortalidad estandarizada en una Unidad de Cuidados Intensivos polivalente de la Argentina
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Archivos suplementarios

Gráfico 1. Curvas COR para predecir mortalidad con escores APACHE II y SAPS II.
Tabla 1. Valores de los componentes del APACHE II en el grupo de sobrevivientes y fallecidos.
Tabla 2. Puntajes asignados por cada variable del SAPS II en el grupo de sobrevivientes y fallecidos.
Tabla 3. Área bajo la curva
Tabla 1. Características de los pacientes sobrevivientes y fallecidos
Tabla 2. Calibración de los puntajes APACHE II y SAPS II
Tabla 3. Áreas bajo la curva con sus respectivos intervalos de confianza
Figura. Curvas ROC para predecir la mortalidad con los puntajes APACHE II y SAPS II

Palabras clave

APACHE
mortalidad
terapia intensiva
indicadores de calidad

Cómo citar

1.
Rocchetti NS, Bagilet DH, Settecase CJ, Quaglino M. Desempeño de los puntajes APACHE II y SAPS II para calcular la razón de mortalidad estandarizada en una Unidad de Cuidados Intensivos polivalente de la Argentina. Rev Arg de Ter Int. [Internet]. 22 de febrero de 2016 [citado 28 de marzo de 2024];33(1). Disponible en: https://revista.sati.org.ar/index.php/MI/article/view/437

Resumen

OBJETIVO: Estudiar el desempeño del Acute Physiology and Chronic Health

Evaluation II (APACHE II), y el Simplified Acute Physiologic Score (SAPS II) para el cálculo de la razón de mortalidad estandarizada (RME) en nuestra UCI.

DISEÑO: Estudio retrospectivo y observacional realizado entre el 01/01/2007 y el 31/12/2013.

ÁMBITO: Unidad de Cuidados Intensivos polivalente.

PACIENTES: Mayores de 18 años, de ambos sexos, internados al menos durante 24 horas.

INTERVENCIONES: Ninguna.

VARIABLES DE INTERÉS: APACHE II, SAPS II, mortalidad, RME.

RESULTADOS: Se analizaron 2.641 pacientes que reunieron todos los datos requeridos. Edad promedio: 50,14 (± 16,95) años, varones: 67%, promedio de internación: 6,79 (± 9,14) días, mortalidad 23,82%. Mortalidad promedio estimada por APACHE II 21,8% (± 21,4) y por SAPS II 27,4% (± 29,1) (p 0,000). La RME para la población estudiada utilizando APACHE II fue de 1,09 (IC 95%: 1,01-1,18) y SAPS II fue de 0,87 (IC 95%: 0,80-0,93). El APACHE II tuvo una adecuada calibración pero no así el SAPS II (Test de Hosmer-Lemeshow: p=0,4042 y p=0,0024 respectivamente). La discriminación del APACHE II y SAPS II fue buena (AUC: 0,830 ±0,010, p < 0,001, IC 95% 0,811 – 0,849 y AUC: 0,836 ±0,001, p < 0,001, IC 95% 0,818 – 0,854 respectivamente).

CONCLUSIONES: A partir de estos resultados podemos concluir que el APACHE II tuvo buena discriminación y calibración, mientras que el SAPS II tuvo buena discriminación y mala calibración. Por lo tanto, en nuestra UCI sería razonable el empleo del APACHE II para el cálculo de la RME.

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Citas

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Milbank Q. 2005; 83(4): 691-729.</span></p> <p class="MsoNormal" style="margin-left: 0cm; text-align: justify; text-indent: -18.0pt; line-height: 200%; mso-list: l0 level1 lfo1; tab-stops: list 18.0pt;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: Arial; mso-ansi-language: IT;" lang="IT"><span style="mso-list: Ignore;">13.<span style="font: 7.0pt &quot;Times New Roman&quot;;"> </span></span></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">Sitio web del software SATI-Q: http://www.hardineros.com.ar/satiq/</span></p> <p class="MsoNormal" style="margin-left: 0cm; text-align: justify; text-indent: -18.0pt; line-height: 200%; mso-list: l0 level1 lfo1; tab-stops: list 18.0pt;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: Arial; mso-ansi-language: IT;" lang="IT"><span style="mso-list: Ignore;">14.<span style="font: 7.0pt &quot;Times New Roman&quot;;"> </span></span></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">Serrano N. Calibration strategies to validate predictive models: is new always better? Inten Care Med 2012; 38(8): 1246&ndash;8.</span></p> <p class="MsoNormal" style="margin-left: 0cm; text-align: justify; text-indent: -18.0pt; line-height: 200%; mso-list: l0 level1 lfo1; tab-stops: list 18.0pt;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: Arial; mso-ansi-language: IT;" lang="IT"><span style="mso-list: Ignore;">15.<span style="font: 7.0pt &quot;Times New Roman&quot;;"> </span></span></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">Diamond G. What price perfection? Calibration and discrimination of clinical prediction models. J Clin Epidemiol 1992; 45(I): 85&ndash;9.</span></p> <p class="MsoNormal" style="margin-left: 0cm; text-align: justify; text-indent: -18.0pt; line-height: 200%; mso-list: l0 level1 lfo1; tab-stops: list 18.0pt;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: Arial; mso-ansi-language: IT;" lang="IT"><span style="mso-list: Ignore;">16.<span style="font: 7.0pt &quot;Times New Roman&quot;;"> </span></span></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">Altman DG, Royston P. What do we mean by validating a prognostic model? Statistics in medicine 2000; 19(4): 453&ndash;73.</span></p> <p class="MsoNormal" style="margin-left: 0cm; text-align: justify; text-indent: -18.0pt; line-height: 200%; mso-list: l0 level1 lfo1; tab-stops: list 18.0pt;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: Arial; mso-ansi-language: IT;" lang="IT"><span style="mso-list: Ignore;">17.<span style="font: 7.0pt &quot;Times New Roman&quot;;"> </span></span></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">Sakr Y, Krauss C, Amaral a CKB, R&eacute;a-Neto a, Specht M, Reinhart K, et al. Comparison of the performance of SAPS II, SAPS 3, APACHE II, and their customized prognostic models in a surgical intensive care unit. Br J Anaesth 2008; 101(6): 798&ndash;803.</span></p> <p class="MsoNormal" style="margin-left: 0cm; text-align: justify; text-indent: -18.0pt; line-height: 200%; mso-list: l0 level1 lfo1; tab-stops: list 18.0pt;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: Arial; mso-ansi-language: IT;" lang="IT"><span style="mso-list: Ignore;">18.<span style="font: 7.0pt &quot;Times New Roman&quot;;"> </span></span></span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Arabi%20Y%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=11983044"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Arabi Y</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Haddad%20S%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=11983044"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Haddad S</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Goraj%20R%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=11983044"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Goraj R</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Al-Shimemeri%20A%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=11983044"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Al-Shimemeri A</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Al-Malik%20S%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=11983044"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Al-Malik S</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">. Assessment of performance of four mortality prediction systems in a Saudi Arabian intensive care unit. </span><span lang="ES"><a title="Critical care (London, England)." href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Assessment+of+performance+of+four+mortality+prediction+systems+in+a+Saudi+Arabian+intensive+care+unit+Yaseen+Arabi"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Crit Care.</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT"> 2002 Apr; 6(2): 166-74.</span></p> <p class="MsoNormal" style="margin-left: 0cm; text-align: justify; text-indent: -18.0pt; line-height: 200%; mso-list: l0 level1 lfo1; tab-stops: list 18.0pt;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: Arial; mso-ansi-language: IT;" lang="IT"><span style="mso-list: Ignore;">19.<span style="font: 7.0pt &quot;Times New Roman&quot;;"> </span></span></span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Livingston%20BM%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10890627"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Livingston BM</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=MacKirdy%20FN%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10890627"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">MacKirdy FN</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Howie%20JC%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10890627"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Howie JC</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Jones%20R%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10890627"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Jones R</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Norrie%20JD%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10890627"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Norrie JD</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">. Assessment of the performance of five intensive care scoring models within a large Scottish database. </span><span lang="ES"><a title="Critical care medicine." href="http://www.ncbi.nlm.nih.gov/pubmed/10890627"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Crit Care Med.</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT"> 2000; 28(6): 1820-7.</span></p> <p class="MsoNormal" style="margin-left: 0cm; text-align: justify; text-indent: -18.0pt; line-height: 200%; mso-list: l0 level1 lfo1; tab-stops: list 18.0pt;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: Arial; mso-ansi-language: IT;" lang="IT"><span style="mso-list: Ignore;">20.<span style="font: 7.0pt &quot;Times New Roman&quot;;"> </span></span></span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Castella%20X%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=7634802"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Castella X</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Artigas%20A%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=7634802"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Artigas A</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Bion%20J%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=7634802"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Bion J</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Kari%20A%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=7634802"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Kari A</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">. A comparison of severity of illness scoring systems for intensive care unit patients: results of a multicenter, multinational study. The European/North American Severity Study Group. </span><span lang="ES"><a title="Critical care medicine." href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Castella+X%2C+a+comparison+of+severity+of+illness+scorin+systems+for+intensive+care"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Crit Care Med.</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT"> 1995; 23(8): 1327-35.</span></p> <p class="MsoNormal" style="margin-left: 0cm; text-align: justify; text-indent: -18.0pt; line-height: 200%; mso-list: l0 level1 lfo1; tab-stops: list 18.0pt;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: Arial; mso-ansi-language: IT;" lang="IT"><span style="mso-list: Ignore;">21.<span style="font: 7.0pt &quot;Times New Roman&quot;;"> </span></span></span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Del%20Bufalo%20C%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10152703"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Del Bufalo C</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Morelli%20A%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10152703"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Morelli A</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Bassein%20L%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10152703"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Bassein L</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Fasano%20L%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10152703"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Fasano L</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Quarta%20CC%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10152703"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Quarta CC</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Pacilli%20AM%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10152703"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Pacilli AM</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">, </span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Gunella%20G%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10152703"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Gunella G</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">. Severity scores in respiratory intensive care: APACHE II predicted mortality better than SAPS II. </span><span lang="ES"><a title="Respiratory care." href="http://www.ncbi.nlm.nih.gov/pubmed/10152703"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; color: windowtext; mso-ansi-language: IT; text-decoration: none; text-underline: none;" lang="IT">Respir Care.</span></a></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT"> 1995; 40(10): 1042-7.</span></p> <p class="MsoNormal" style="margin-left: 0cm; text-align: justify; text-indent: -18.0pt; line-height: 200%; mso-list: l0 level1 lfo1; tab-stops: list 18.0pt;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: Arial; mso-ansi-language: IT;" lang="IT"><span style="mso-list: Ignore;">22.<span style="font: 7.0pt &quot;Times New Roman&quot;;"> </span></span></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">Lee H, Shon YJ, Kim H, Paik H, Park HP. Validation of the APACHE IV model and its comparison with the APACHE II, SAPS 3, and Korean SAPS 3 models for the prediction of hospital mortality in a Korean surgical intensive care unit. Korean J Anesthesiol. 2014 Aug; 67(2): 115-22.</span></p> <p class="MsoNormal" style="margin-left: 0cm; text-align: justify; text-indent: -18.0pt; line-height: 200%; mso-list: l0 level1 lfo1; tab-stops: list 18.0pt;"><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-fareast-font-family: Arial; mso-ansi-language: IT;" lang="IT"><span style="mso-list: Ignore;">23.<span style="font: 7.0pt &quot;Times New Roman&quot;;"> </span></span></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: IT;" lang="IT">Giraldo N, Toro JM, Cadavid C, Zapata F, Jaimes F. Performance of APACHE II and SAPS 3 Regional adaptation in a population of critically Ill patients in Colombia. 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Priority="39" QFormat="true" Name="TOC Heading" /> </w:LatentStyles> </xml><![endif]--><!--[if gte mso 10]> <mce:style><! /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} --> <!--[endif] --></p><p class="MsoNormal" style="margin-left:0cm;text-align:justify;text-indent:-18.0pt; line-height:200%;mso-list:l0 level1 lfo1;tab-stops:list 18.0pt"><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;mso-fareast-font-family:Arial; mso-ansi-language:IT" lang="IT"><span style="mso-list:Ignore">1.<span style="font:7.0pt &quot;Times New Roman&quot;">&nbsp;&nbsp;&nbsp; </span></span></span><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;; mso-ansi-language:IT" lang="IT">Serpa Neto A, Assun&ccedil;&atilde;o MS, Pardini A, Silva E. Feasibility of transitioning from APACHE II to SAPS III as prognostic model in a Brazilian general intensive care unit. A retrospective study. Sao Paulo Med J. 2015 May-Jun; 133(3): 199-205.</span></p> <p>&nbsp;</p>

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