Use of elective non-invasive ventilation in a Pediatric Intensive Care Unit
Main Article Content
Abstract
Elective non-invasive ventilation (eNIV) is an alternative to avoid intubation and invasive mechanical ventilation (IMV) in the treatment of acute respiratory failure in infants and children, reducing morbidity and mortality and hospitalization days.
Objective: To know the success rate of using eNIV in patients admitted to a pediatric intensive care unit (PICU) and explore factors associated with success.
Design: Descriptive, observational and retrospective.
Methods: Data from patients who entered eVNI between 2021 and 2023 were collected from the pediatric kinesiology team database and corroborated with the digital medical records of each patient. Age, sex, Pediatric Mortality Index 3 (PIM 3), diagnosis, comorbidities, days of eNIV, SpO2/FIO2 onset index (SaFiO2), causes of eNIV failure, and days of hospitalization were collected. Successful eNIV was considered when there was no need for intubation.
Results: Of the 780 patients admitted to the PICU between January 2021 and August 2023, 159 required eNIV. The success rate was 71.1%. Initial SaFiO2 was identified in a statistically significant and independent manner with the success of eNIV. The eNIV success group remained hospitalized for 7 days (IQR 6-9), while the failure group remained hospitalized for 14.5 days (IQR 11-21) (p<0.001).
Conclusion: Successful eNIV prevented a high percentage of patients from being admitted to intubation and IMV. Initial SaFiO2 was found to be a significant and independent variable with the success of eNIV
Article Details

This work is licensed under a Creative Commons Attribution 4.0 International License.
The magazine does not retain the reproduction rights (copyright) so the authors can republish their works with the sole mention of the original publication source.
References
Comité de Neumonología; Comité de Infectología; Comité de Medicina Interna Pediátrica; Comité de Pediatría Ambulatoria y Colaboradores; Comité de Pediatría Ambulatoria. Recomendaciones para el manejo de las infecciones respiratorias agudas bajas en menores de 2 años. Actualización 2021 [Recommendations for the management of acute lower respiratory infections in children under 2 years of age. Update 2021]. Arch Argent Pediatr. 2021 Aug;119(4):S171-S197.
Vivero, P., Tarazona, S. y Cimadevilla, R. (2017). Fracaso respiratorio agudo y crónico. Oxigenoterapia. Protoc diagn ter pediatr.;1:369-399.
2008 Introduction to the NEDS. Healthcare Cost and Utilization Project (HCUP). June 2016. Agency for Healthcare Research and Quality, Rockville, MD. www.hcup-us.ahrq.gov/db/nation/neds/NEDS_Introduction_2008.jsp?_gl=1933wwe_gaMTA4MzQ3Mzc1MS4xNzIzMjIyNTI4_ga_45NDTD15CJMTcyMzIyMzE5NC4xLjAuMTcyMzIyMzE5NC42MC4wLjA..
Farias, J. A., Fernández, A. Monteverde, Latin-American Group for Mechanical Ventilation in Children. (2012). Mechanical ventilation in pediatric intensive care units during the season for acute lower respiratory infection: a multicenter study. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 13(2), 158–164.
Essouri S, Chevret L, Durand P, Haas V, et al. (2006). Noninvasive positive pressure ventilation: Five years of experience in a pediatric intensive care unit. Pediatr Crit Care Med; 7(4): 329-34.
Yañez L, Yunge M, Emilfork M, Lapadula M, et al. (2008) A prospective, randomized, controlled trial of noninvasive ventilation in pediatric acute respiratory failure. Pediatr Crit Care Med; 9(5): 484-89.
Lins, A. R. B. D. S., Duarte, M. D. C. M. B., y Andrade, L. B. (2019). Noninvasive ventilation as the first choice of ventilatory support in children. Revista Brasileira de terapia intensiva, 31(3), 333–339.
Norregaard O. (2002). Noninvasive ventilation in children Eur Respir J; 20(5): 1332-42.
Prado F, Godoy MA, Godoy M, Boza ML.(2005).Ventilación no invasiva como tratamiento de la insuficiencia respiratoria aguda en Pediatría. Rev Med Chile; 133(5):525-33.
Teague G. (2003). Noninvasive ventilation in the pediatric intensive care unit for children with acute respiratory failure. Pediatr Pulmonol; 35(6): 418-26.
Lule Morales M, de la Rosa Rodríguez A, Robledo Pascual J, Narváez Porras O y Niebla Álvarez B. (2004). Eficiencia de la ventilación mecánica no invasiva en pacientes pediátricos con insuficiencia respiratoria aguda. Rev Inst Nal Enf Resp Mex; 17(3):181-91.
Loh L, Chan Y y Chan I. (2007). Noninvasive ventilation in children: a review. J Pediatr (Rio J); 83(2 Suppl): S91-99.
Tal A, Ravilski C, Yohai D, et al. (1983). Dexamethasone and salbutamol in the treatment of acute wheezing in infants. Pediatrics;71:13.
Wood D, Downes J, Lecks H. (1972). A clinical scoring system for diagnosis of respiratory failure. AJDC; 123:227-228.
Akaike H. Statistical predictor identification. (1970). Ann Inst Math Stat. 1970;22:203-17.
Fischer JE, Bachmann LM, Jaeschke R (2003) A readers’ guide to the interpretation of diagnostic test properties: clinical example of sepsis. Intensive Care Med 29(7):1043–1051.
Pons-Òdena M, Medina A, Modesto V, Martín-Mateos MA, Tan W, Escuredo L, Cambra FJ. ¿Cuáles son los factores predictores de fracaso de ventilación no invasiva más fiables en una unidad de cuidados intensivos pediátricos? An Pediatr. 2019 Nov;91(5):307-316.
Bonora J.P., Frachia D., M. García, et al.(2011) VNI en cuidado Intensivo Pediátrico, 4 años de experiencia. Argent Pediatr, 109(2):124-128/124
J.Mayordomo Colunga. M. Pons Y. Lopez, et al. (2013) Predicting non-invasive ventilation failure in children from the SpO2/FiO2 (SF) ratio. Intensive Care Med.
M. Pons-Odenaa , D. Palancaa, V. Modestoc, et al. (2013) SpO2/FiO2 as a predictor of non-invasive ventilation failure in children with hypoxemic respiratory insufficiency. Journal of Pediatric Intensive Care 2, 111–119. Disponible en: DOI 10.3233/PIC-13059
Toobe M. (2021). Síndrome post cuidados intensivos en pediatría. Rev Fac Cien Med Univ Nac Cordoba.;78(4):408-14.
Ganu, S. S., Gautam, A., Wilkins, B., & Egan, J. (2012). Increase in use of non-invasive ventilation for infants with severe bronchiolitis is associated with decline in intubation rates over a decade. Intensive care medicine, 38(7), 1177–1183.
Alonso B., Boulay, M., Dall Orso, P., et al. (2012). Ventilación no invasiva en menores de dos años internados en sala con infección respiratoria aguda baja. Posibles factores predictivos de éxito y de fracaso. Archivos de Pediatría del Uruguay; 83(4): 250-255.
Kneyber, M. C. J., de Luca, D Calderini, E., et al. (2017) Recommendations for mechanical ventilation of critically ill children from the Paediatric Mechanical Ventilation Consensus Conference (PEMVECC). Intensive care medicine, 43(12), 1764–1780.